BIOC 212

McGill

Course Overview

Lessons & Practice

I. Welcome

2 min

1. Amino Acids Structure and Properties

1.1hr

1.1.1. Amino Acids10 min

1.1.2. Example: Similar Amino Acids3 min

1.1.3. Example: Directed Mutagenesis3 min

1.2.1. Acids-Base Definitions, pH, pKa5 min

1.2.2. pKa and Ionization State8 min

1.2.3. pKa of Amino Acids10 min

1.2.4. Amino Acid Isoelectric Point5 min

1.2.5. Practice: pKa of Side Chains4 min

1.3.1. Peptide Bond6 min

1.3.2. Peptide Bond Angles3 min

1.3.3. Example: Peptide Chain4 min

1.3.4. Example: Peptide Bond Angles2 min

1.3.5. Practice: Peptide Bond Resonance2 min

1.4.1. Buffers4 min

1.Q. Amino Acids: Checkpoint Quiz7 Qns

1.P.1. Practice: Role of Amino Acids in an Active Site

1.P.2. Practice: Amino Acids

2. Protein Structure and Folding

1.4hr

2.1.1. Primary and Secondary Protein Structure5 min

2.1.2. Example: Point Mutation in Secondary Structure3 min

2.2.1. α-helix3 min

2.2.2. Properties of α-helix5 min

2.2.3. Example: Properties of an Alpha Helix3 min

2.2.4. Example: Point Mutation in Alpha Helix4 min

2.2.5. Practice: Alpha-Helix3 min

2.3.1. β-Sheet4 min

2.3.2. β-turns and loops5 min

2.3.3. Example: Beta-Turns2 min

2.3.4. Example: H-bonding in Beta-Sheets2 min

2.3.5. Example: Beta-Barrel Channels4 min

2.3.6. Practice: Stacked Beta-Sheets

2.4.1. Tertiary and Quarternary Protein Structure9 min

2.4.2. Example: Tertiary Structure (Motifs)3 min

2.4.3. Practice: Quaternary Structure3 min

2.5.1. Ramachandran Plot3 min

2.5.2. Example: Ramachandran Plot3 min

2.6.1. Anfinsen's Experiment8 min

2.6.2. Thermodynamics of Protein Folding7 min

2.6.3. Example: Urea2 min

2.6.4. Practice: Protein Folding2 min

2.Q. Protein Structure: Checkpoint Quiz5 Qns

2.P.1. Practice: Hydrophobicity Scale

2.P.2. Practice: Thermophilic Proteins

3. Membrane Protein & Transporters

1.3hr

3.1.1. Proteins in the Lipid Bilayer1 min

3.1.2. Peripheral Membrane Proteins5 min

3.1.3. Integral Membrane Proteins5 min

3.1.4. Measuring Hydrophobicity7 min

3.1.5. Membrane Protein Folding2 min

3.1.6. Practice: Peripheral Membrane Proteins1 min

3.1.7. Practice: Integral Membrane Proteins1 min

3.1.8. Practice: Hydropathy49 sec

3.1.9. Practice: Integral Membrane Proteins55 sec

3.2.1. Membrane Proteins4 min

3.2.2. Practice: Membrane Proteins

3.3.1. Bacteriorhodopsin4 min

3.3.2. Porins2 min

3.3.3. Example: Bacteriorhodopsin1 min

3.3.4. Example: Membrane Proteins1 min

3.4.1. Introduction and Passive Transport7 min

3.4.2. Active Transport7 min

3.4.3. Transport Proteins: Ion Channels4 min

3.4.4. Example: Active vs. Passive Transport5 min

3.4.5. Practice: Potassium Ion Channels59 sec

3.5.1. Ion Channel Receptors2 min

3.5.2. G-Protein Coupled Receptors (GPCRs)7 min

3.5.3. Receptor Tyrosine Kinases (RTKs)5 min

3.5.4. Example: G-protein Coupled Receptors1 min

3.Q. Checkpoint Quiz4 Qns

3.P.1. Practice: G-Protein Coupled Receptors

3.P.2. Practice: Predicting transmembrane segments

4. Cell Structure

1.7hr

4.1.1. Prokaryotic Cells5 min

4.1.2. Practice 1

4.1.3. Bacteria and Archaea Cell Wall Composition4 min

4.1.4. Practice 2

4.1.5. Practice 3

4.2.1. Eukaryotic Cells11 min

4.2.2. Illustrations of Cellular Components7 min

4.2.3. Practice 1

4.2.4. Practice 2

4.3.1. Eukaryotic Cells [Introduction for detailed courses]2 min

4.3.2. Ribosomes 3 min

4.3.3. Peroxisomes3 min

4.3.4. Mitochondria and Chloroplasts6 min

4.3.5. Plant versus Animal Cells3 min

4.4.1. Endosymbiont Theory5 min

4.5.1. The Endomembrane System2 min

4.5.2. The Nucleus5 min

4.5.3. The Endoplasmic Reticulum (ER)4 min

4.5.4. The Golgi Apparatus3 min

4.5.5. Lysosomes, Vacuoles and Vesicles

4.6.1. Cytoskeleton Overview [short lesson]5 min

4.6.2. Microtubules6 min

4.6.3. Actin Microfilaments4 min

4.6.4. Intermediate Filaments3 min

4.6.5. Practice 1

4.6.6. Practice 2

4.6.7. Illustrations of the Cytoskeleton4 min

4.7.1. Motor Proteins5 min

4.7.2. Flagella and Cilia3 min

4.7.3. Practice 1

4.7.4. Practice 2

4.8.1. Extracellular Matrix2 min

4.8.2. Junctions and Adhesions5 min

4.8.3. Practice 1

4.8.4. Practice 2

4.8.5. Practice 3

6. Energy & Metabolism

2.1hr

6.1.1. Overview of Metabolism4 min

6.1.2. Nutrients Required by Cells4 min

6.1.3. Practice 11 min

6.1.4. Practice 22 min

6.1.5. Practice 32 min

6.2.1. Redox (Reduction-Oxidation) Reactions7 min

6.2.2. Practice 13 min

6.2.3. Practice 23 min

6.3.1. The Laws of Thermodynamics8 min

6.3.2. Example 2 min

6.3.3. Practice2 min

6.4.1. Potential and Kinetic Energies3 min

6.4.2. Practice 11 min

6.4.3. Energy in Reactions7 min

6.4.4. Example 15 min

6.4.5. Activation Energy3 min

6.4.6. Gibbs Free Energy8 min

6.4.7. Practice 22 min

6.5.1. Coupled Reactions6 min

6.5.2. Example 1 min

6.5.3. Practice 1

6.5.4. Practice 22 min

6.6.1. ATP and the Proton Motive Force (PMF)6 min

6.6.2. Example1 min

6.6.3. Practice 2 min

6.7.1. Enzymes6 min

6.7.2. Enzyme Activity4 min

6.7.3. Example1 min

6.7.4. Practice 1 min

6.8.1. Enzyme Regulation10 min

6.8.2. Feedback Inhibition3 min

6.8.3. Example 13 min

6.8.4. Example 26 min

6.8.5. Practice 12 min

7. Cellular Respiration

1.5hr

7.1.1. Overview of Cellular Respiration4 min

7.2.1. Glycolysis4 min

7.2.2. Practice 1

7.2.3. Practice 22 min

7.2.4. Practice 3

7.3.1. Steps of Glycolysis: Intro and Stage I [Detailed]7 min

7.3.2. Steps of Glycolysis: Stages II and III [Detailed]9 min

7.4.1. Energy of Glucose Metabolism7 min

7.4.2. Practice 1

7.5.1. Glycolysis Regulation8 min

7.5.2. Practice 1

7.5.3. Practice 2

7.6.1. Glycolysis Full Sequence of Reactions and Summary [detailed]8 min

7.7.1. Pyruvate Processing4 min

7.7.2. Practice 1

7.8.1. The Citric Acid Cycle3 min

7.8.2. Practice 12 min

7.8.3. Practice 2

7.8.4. Practice 3

7.9.1. The Citric Acid Cycle - Substrates and Enzymes [detailed]10 min

7.9.2. Practice 1

7.9.3. Practice 2

7.9.4. Practice 3

7.10.1. Utilization of TCA Intermediates2 min

7.11.1. Electron Transport Chain Overview3 min

7.11.2. Example

7.11.3. Practice 12 min

7.11.4. Practice 23 min

7.12.1. The Electron Transport Chain8 min

7.13.1. Fermentation3 min

7.13.2. Practice 1

7.13.3. Practice 2

7.13.4. Practice 3

9. Meiosis

25min

9.1.1. Meiosis I10 min

9.1.2. Chromosomal Crossover3 min

9.1.3. Meiosis Nomenclature3 min

9.1.4. Practice 1

9.1.5. Practice 2

9.1.6. Practice 3

9.2.1. Meiosis II5 min

9.2.2. Example: Graphing Ploidy & C-value Coefficients4 min

10. Cancer

36min

10.1.1. Causes of Cancer14 min

10.1.2. How does cancer grow?7 min

10.1.3. Cancer Treatments9 min

10.1.4. Example: Cancer Causes3 min

10.1.5. Example: Cancer Treatment3 min

10.Q. Cancer Checkpoint Quiz5 Qns

11. Cell Communication

1.3hr

11.1.1. Types of Cell Communication 10 min

11.1.2. Practice 13 min

11.1.3. Practice 22 min

11.1.4. Practice 32 min

11.2.1. Internal Receptors4 min

11.2.2. G-Protein Coupled Receptors (GPCRs)7 min

11.2.3. Receptor Tyrosine Kinases (RTKs)5 min

11.2.4. Ion Channel Receptors2 min

11.2.5. Practice 12 min

11.2.6. Practice 22 min

11.2.7. Practice 33 min

11.3.1. Signal Transduction6 min

11.3.2. Practice 12 min

11.3.3. Practice 21 min

11.4.1. Second Messengers5 min

11.4.2. Practice 12 min

11.5.1. Second Messengers9 min

11.5.2. Practice 12 min

11.5.3. Practice 22 min

11.6.1. Response to Signaling5 min

11.6.2. Practice 12 min

11.6.3. Practice 22 min

12. DNA Replication & Repair

2.4hr

12.1.1. Review of DNA Structure10 min

12.1.2. Practice 12 min

12.1.3. Practice 2

12.2.1. Meselson-Stahl Experiment9 min

12.2.2. Example: Applying the Meselson-Stahl Experiment2 min

12.2.3. Practice 12 min

12.3.1. DNA Replication in Cells14 min

12.3.2. Example: Leading and Lagging Strands2 min

12.3.3. Practice 12 min

12.3.4. Practice 23 min

12.3.5. Example: Complete the Replication Bubble4 min

12.4.1. Telomerase4 min

12.4.2. Practice 11 min

12.4.3. Practice 22 min

12.5.1. Types of DNA Mutations9 min

12.5.2. Practice 1

12.5.3. Practice 2

12.5.4. Sources of Mutation: Tautomeric Shifts7 min

12.5.5. Example: Tautomeric Shifts4 min

12.5.6. Sources of Mutation: DNA Slippage5 min

12.5.7. Sources of Mutation: Copy Number Variations3 min

12.5.8. Sources of Mutation: Mobile Elements7 min

12.6.1. Repair of Mutations During Replication [Exonuclease Activity and Mismatch Repair]10 min

12.6.2. Repair of Mutations by Mutagens [Nucleotide Excision Repair]3 min

12.6.3. Practice 12 min

12.7.1. Repair of DNA Double Stranded Breaks [detailed]9 min

12.7.2. Practice 12 min

12.8.1. Polymerase Chain Reaction (PCR)10 min

12.8.2. Primer Design3 min

12.8.3. Example 15 min

12.8.4. Practice 12 min

12.8.5. Practice 2

13. Transcription and Translation

1.8hr

13.1.1. The Central Dogma of Biology4 min

13.1.2. Practice 1

13.1.3. Practice 22 min

13.1.4. Practice 32 min

13.2.1. Genes and mRNA8 min

13.2.2. General Structure of mRNA4 min

13.2.3. The Genetic Code8 min

13.2.4. Reading Frame3 min

13.2.5. Practice 13 min

13.2.6. Practice 22 min

13.2.7. Practice 32 min

13.2.8. Practice 43 min

13.2.9. Summary of Genes and mRNA

13.3.1. Initiation8 min

13.3.2. Elongation7 min

13.3.3. Termination4 min

13.3.4. Practice 14 min

13.3.5. Practice 22 min

13.3.6. Practice 3

13.4.1. Transcription In Eukaryotes9 min

13.4.2. Practice 1

13.5.1. RNA Maturation in Eukaryotes8 min

13.5.2. Example 3 min

13.5.3. Practice 11 min

13.5.4. Practice 23 min

13.5.5. mRNA Maturation - Theory3 min

13.6.1. Translation into Proteins9 min

13.6.2. Differences in Eukaryotic and Prokaryotic Translation3 min

13.6.3. Example 15 min

13.6.4. Example 2

13.6.5. Transcription vs. Translation Chart

13.6.6. Practice 1

13.6.7. Practice 2

14. Gene Expression & Regulation

1.2hr

14.1.1. Introduction to Regulation of Gene Expression4 min

14.1.2. Prokaryotic Levels of Regulation6 min

14.1.3. Prokaryotic Regulatory Proteins5 min

14.1.4. Types of Transcriptional Regulation5 min

14.1.5. Practice 1

14.1.6. Practice 2

14.1.7. Practice 3

14.2.1. The Tryptophan (Trp) Operon5 min

14.2.2. Trp Operon Attenuation8 min

14.2.3. The Trp Operon Summary

14.3.1. The Lac Operon5 min

14.3.2. Practice 1

14.3.3. Practice 2

14.3.4. Practice 3

14.4.1. The Lac Operon [detailed]5 min

14.4.2. The Lac Operon & Glucose Regulation [detailed]5 min

14.4.3. Lac Operon Summary

14.4.4. Example 1

14.4.5. Example 2

14.4.6. Practice 1

14.5.1. The Maltose (mal) Operon 4 min

14.6.1. Epigenetic Gene Regulation5 min

14.6.2. X-Chromosome Inactivation4 min

14.6.3. Practice 1

14.6.4. Practice 2

14.7.1. Transcription Factors, Enhancers and Repressors3 min

14.7.2. Practice 1

14.7.3. Practice 2

14.8.1. Eukaryotic Post-Transcriptional Regulation6 min

14.8.2. Practice 1

14.8.3. Practice 2

14.9.1. Translational and Post-translational Regulation2 min

14.9.2. Practice

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Answered

Aseel Y

Hi there, I just want to ask why Homeostasis section is not available!

Danielle S

Instructor

Thank you for bringing this to our attention and your patience in allowing us to solve the issue!

The chapter now has the content ready for you to explore and review.

Answered

Anonymous

Is glycolysis not covered in this course?

Lila H

Instructor

It is currently included in Section 5 "Energy and Metabolism"

Answered

Anonymous

What is the difference between gene flow and genetic drift 

Isaura F

Instructor

Gene flow is the transfer of genetic information from one population to another. Genetic drift is the variation of the relative frequency of a particular allele (version of a gene) within a population. Hope this helps!

Answered

Shannon W

What's neurons?

Marlon B

A nerve cell

Answered

Alexis E

whats a hydrogen bond?

Marlon B

A bond between an electrostatic attraction between a proton in one molecule and electronegative atom in the other 

Answered

Anonymous

Are there any parts of the human body that get oxygen directly from the air and not from the blood?

Isaura F

Instructor

Seems like the outer layers of skin and outer cornea (of your eyes) are able to get oxygen directly from air. 

Answered

Laura P

How does climate change affect wildlife in ontario? 

Isaura F

Instructor

"In Ontario, [one] can expect average temperatures to rise by as much as 3 to 8 degrees Celsius over the next century. Warmer temperatures will result in milder winters, longer growing seasons and a higher frequency of severe weather events such as record-breaking storms, floods, droughts and heat waves." For more info, check out: http://www.health.gov.on.ca/en/common/ministry/publications/reports/climate_change_toolkit/climate_change_health_modelling_study.pdf

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BIOC 212

Course Overview

1. Amino Acids Structure and Properties

2. Protein Structure and Folding

3. Membrane Protein & Transporters

4. Cell Structure

5. The Plasma Membrane

6. Energy & Metabolism

7. Cellular Respiration

8. The Cell Cycle

9. Meiosis

10. Cancer

11. Cell Communication

12. DNA Replication & Repair

13. Transcription and Translation

14. Gene Expression & Regulation

I Welcome

Free Activity

Ask a Question

Aseel Y

Danielle S

Anonymous

Lila H

Anonymous

Isaura F

Shannon W

Marlon B

Alexis E

Marlon B

Anonymous

Isaura F

Laura P

Isaura F

Welcome to First Year Bio!