BIOL 2581

UWO

Course Overview

Lessons & Practice

I. Welcome

2 min

1. Introduction and the Tree of Life

28min

1.1.1. Descent with Modification6 min

1.2.1. The Modern Synthesis6 min

1.2.2. Practice

1.2.3. Practice

1.3.1. Endosymbiont Theory5 min

1.3.6. Mitochondrial DNA Inheritance3 min

1.3.7. Fission and Fusion of Mitochondria6 min

2. Genome Sequencing

25min

2.1.1. DNA Sequencing9 min

2.1.2. Bioinformatics9 min

2.1.3. Example: Bioinformatics4 min

2.1.4. Practice: BLAST

2.2.1. Gene Mapping4 min

3. Genome Annotation and Variation

4min

3.1.1. Proteomics4 min

3.1.2. Practice 2

4. Origin of Sequence Variation

2.4hr

4.1.1. Review of DNA Structure10 min

4.1.2. Practice 12 min

4.1.3. Practice 2

4.2.1. Meselson-Stahl Experiment9 min

4.2.2. Example: Applying the Meselson-Stahl Experiment2 min

4.2.3. Practice 12 min

4.3.1. DNA Replication in Cells14 min

4.3.2. Example: Leading and Lagging Strands2 min

4.3.3. Practice 12 min

4.3.4. Practice 23 min

4.3.5. Example: Complete the Replication Bubble4 min

4.4.1. Telomerase4 min

4.4.2. Practice 11 min

4.4.3. Practice 22 min

4.5.1. Types of DNA Mutations9 min

4.5.2. Practice 1

4.5.3. Practice 2

4.5.4. Sources of Mutation: Tautomeric Shifts7 min

4.5.5. Example: Tautomeric Shifts4 min

4.5.6. Sources of Mutation: DNA Slippage5 min

4.5.7. Sources of Mutation: Copy Number Variations3 min

4.5.8. Sources of Mutation: Mobile Elements7 min

4.6.1. Repair of Mutations During Replication [Exonuclease Activity and Mismatch Repair]10 min

4.6.2. Repair of Mutations by Mutagens [Nucleotide Excision Repair]3 min

4.6.3. Practice 12 min

4.7.1. Repair of DNA Double Stranded Breaks [detailed]9 min

4.7.2. Practice 12 min

4.8.1. Polymerase Chain Reaction (PCR)10 min

4.8.2. Primer Design3 min

4.8.3. Example 15 min

4.8.4. Practice 12 min

4.8.5. Practice 2

5. Allele Classification and Mendelian Genetics

1.8hr

5.1.1. History of Mendelian Genetics4 min

5.1.2. Basics of Probability for Genetics5 min

5.1.3. Example 12 min

5.1.4. Example 22 min

5.1.5. Practice 1

5.2.1. Alleles3 min

5.2.2. Genotype and Phenotype5 min

5.3.1. Incomplete Dominance and Co-Dominance3 min

5.3.2. Example4 min

5.3.3. Practice 1

5.4.1. Mendel's Law of Segregation10 min

5.4.2. Mendel's Law of Independent Assortment6 min

5.4.3. Punnett Square Rules4 min

5.4.4. Example 15 min

5.4.5. Example 29 min

5.4.10. Cheatsheet: Inheritance Terminology

5.5.1. Forked Line Method5 min

5.5.2. Probability Method4 min

5.5.3. Practice 1

5.5.4. Practice 2

5.6.1. Pedigree Analysis9 min

5.7.1. Inheritance of Autosomal Traits9 min

5.7.2. Example 1

5.7.3. Example 2

5.8.1. Inheritance of X-linked Traits

5.8.2. Example 13 min

5.11.1. Causes of Cancer14 min

5.11.2. Example: Cancer Causes3 min

6. Regulation of Gene Expression in Bacteria and Eukaryotes

4hr

6.1.1. The Central Dogma of Biology4 min

6.1.2. Practice 1

6.1.3. Practice 22 min

6.1.4. Practice 32 min

6.2.1. Genes and mRNA8 min

6.2.2. General Structure of mRNA4 min

6.2.3. The Genetic Code8 min

6.2.4. Reading Frame3 min

6.2.5. Practice 13 min

6.2.6. Practice 22 min

6.2.7. Practice 32 min

6.2.8. Practice 43 min

6.2.9. Summary of Genes and mRNA

6.3.1. Initiation8 min

6.3.2. Elongation7 min

6.3.3. Termination4 min

6.3.4. Practice 14 min

6.3.5. Practice 22 min

6.3.6. Practice 3

6.4.1. Transcription In Eukaryotes9 min

6.4.2. Practice 1

6.4.3. Prokaryotic vs. Eukaryotic Transcription7 min

6.4.4. General Transcription Factors (GTFs)5 min

6.4.5. Regulation of Eukaryotic Transcription12 min

6.4.6. Chromatin state and histone modifications7 min

6.4.7. mRNA Processing10 min

6.4.8. Example: mRNA Processing2 min

6.4.9. Example: mRNA Transcript2 min

6.4.10. Practice: Prokaryotic vs. Eukaryotic Transcription

6.4.11. Practice: General Transcription Factors

6.5.1. RNA Maturation in Eukaryotes8 min

6.5.2. Example 3 min

6.5.3. Practice 11 min

6.5.4. Practice 23 min

6.5.5. mRNA Maturation - Theory3 min

6.6.1. Translation into Proteins9 min

6.6.2. Differences in Eukaryotic and Prokaryotic Translation3 min

6.6.3. Example 15 min

6.6.4. Example 2

6.6.5. Transcription vs. Translation Chart

6.6.6. Practice 1

6.6.7. Practice 2

6.7.1. Introduction to Regulation of Gene Expression4 min

6.7.2. Prokaryotic Levels of Regulation6 min

6.7.3. Prokaryotic Regulatory Proteins5 min

6.7.4. Types of Transcriptional Regulation5 min

6.7.5. Practice 1

6.7.6. Practice 2

6.7.7. Practice 3

6.8.1. The Tryptophan (Trp) Operon5 min

6.8.2. Trp Operon Attenuation8 min

6.8.3. The Trp Operon Summary

6.9.1. The Lac Operon5 min

6.9.2. Practice 1

6.9.3. Practice 2

6.9.4. Practice 3

6.10.1. The Lac Operon [detailed]5 min

6.10.2. The Lac Operon & Glucose Regulation [detailed]5 min

6.10.3. Lac Operon Summary

6.10.4. Example 1

6.10.5. Example 2

6.10.6. Practice 1

6.11.1. The Maltose (mal) Operon 4 min

6.12.1. Transcription Factors, Enhancers and Repressors3 min

6.12.2. Practice 1

6.12.3. Practice 2

6.13.1. Eukaryotic Post-Transcriptional Regulation6 min

6.13.2. Practice 1

6.13.3. Practice 2

6.14.1. Translational and Post-translational Regulation2 min

6.14.2. Practice

7. Genetic Screens and Making Mutants

57min

7.1.1. Basics of Genetic Engineering2 min

7.1.2. DNA Manipulation5 min

7.1.3. Plasmids7 min

7.1.4. Restriction Enzymes7 min

7.1.5. PCR8 min

7.1.6. Example: Palindromic Sequence2 min

7.1.7. Example: Cloning Process5 min

7.1.8. Practice: Cloning Plasmids2 min

7.2.1. Genome Editing11 min

7.2.2. CRISPR [detailed]9 min

7.2.3. Practice 1

7.2.4. Practice 2

8. Epistasis and Developmental Genetics

12min

8.1.1. Blood Types2 min

8.1.2. Practice 1

8.1.3. Pleiotropy, Epistasis and Polygenic Inheritance5 min

8.1.4. Practice 2

8.1.5. Example: Epistasis5 min

8.1.6. Practice 3

9. Epigenetics and Microbes

14min

9.1.1. Epigenetic Gene Regulation5 min

9.1.2. X-Chromosome Inactivation4 min

9.1.3. Practice 1

9.1.4. Practice 2

9.2.1. Lateral Gene Transfer5 min

10. Sex and Meiosis

1.4hr

10.1.1. Mutations and Excision Repair14 min

10.1.2. DNA recombination10 min

10.1.3. Example: Mutations4 min

10.1.4. Example: Recombination3 min

10.1.5. Practice: DNA Polymerase

10.2.1. Mitosis and Cytokinesis7 min

10.2.2. Practice 13 min

10.2.3. Practice 23 min

10.2.4. Practice 3

10.2.5. Practice 4

10.2.6. Ploidy & C-value coefficients5 min

10.3.1. Meiosis I10 min

10.3.2. Chromosomal Crossover3 min

10.3.3. Meiosis Nomenclature3 min

10.3.4. Practice 1

10.3.5. Practice 2

10.3.6. Practice 3

10.4.1. Meiosis II5 min

10.4.2. Example: Graphing Ploidy & C-value Coefficients4 min

10.5.1. Genetic Linkage4 min

10.5.2. Recombination Frequencies and Linkage Maps6 min

10.6.1. Karyotyping3 min

10.6.2. Practice

11. Chromosomal mutants

19min

11.1.1. Duplications, Deletions and Inversions4 min

11.1.2. Practice 1

11.2.1. Chromosomal Nondisjunction, Aneuploidy and Polyploidy6 min

11.2.2. Example2 min

11.2.3. Practice 1

11.2.4. Practice 27 min

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Answered

Aseel Y

Hi there, I just want to ask why Homeostasis section is not available!

Danielle S

Instructor

Thank you for bringing this to our attention and your patience in allowing us to solve the issue!

The chapter now has the content ready for you to explore and review.

Answered

Anonymous

Is glycolysis not covered in this course?

Lila H

Instructor

It is currently included in Section 5 "Energy and Metabolism"

Answered

Anonymous

What is the difference between gene flow and genetic drift 

Isaura F

Instructor

Gene flow is the transfer of genetic information from one population to another. Genetic drift is the variation of the relative frequency of a particular allele (version of a gene) within a population. Hope this helps!

Answered

Shannon W

What's neurons?

Marlon B

A nerve cell

Answered

Alexis E

whats a hydrogen bond?

Marlon B

A bond between an electrostatic attraction between a proton in one molecule and electronegative atom in the other 

Answered

Anonymous

Are there any parts of the human body that get oxygen directly from the air and not from the blood?

Isaura F

Instructor

Seems like the outer layers of skin and outer cornea (of your eyes) are able to get oxygen directly from air. 

Answered

Laura P

How does climate change affect wildlife in ontario? 

Isaura F

Instructor

"In Ontario, [one] can expect average temperatures to rise by as much as 3 to 8 degrees Celsius over the next century. Warmer temperatures will result in milder winters, longer growing seasons and a higher frequency of severe weather events such as record-breaking storms, floods, droughts and heat waves." For more info, check out: http://www.health.gov.on.ca/en/common/ministry/publications/reports/climate_change_toolkit/climate_change_health_modelling_study.pdf

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