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A certain X-linked dominant disease in humans occurs when there are more than 3…

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Wize University Biology Textbook > Mendelian Genetics

Inheritance of X-Linked Traits

4 Activities

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Mark Yourself Question
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A certain X-linked dominant disease in humans occurs when there are more than 30 repeats of a GAC trinucleotide in a particular gene. The unique sequence outside the repeat region is as follows:
5' CAGTATGCA------(GAC)n-------ATGCGTAAT 3'
3' GTCATACGT------(GAC)n-------TACGCATTA 5'
Shown below is the outline of a pedigree for the disease described above, and a representation of a gel showing PCR-amplified fragments detecting the number of GAC repeats. The DNA corresponding to each individual is directly below his or her place in the pedigree. Based on the information you have been given, fill/draw in the pedigree to show the sex of the individual as well as the phenotype (affected vs. unaffected).



More Inheritance of X-Linked Traits Questions:
Inheritance of traits practice problem 3
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
Dihybrid cross
Why are sex-linked diseases more likely to affect males?
Dihybrid cross
Why are sex-linked diseases more likely to affect males?
Inheritance of traits practice problem 3
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Pedigree practice problem 2
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Pedigree practice problem
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Inheritance of traits
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
How would you determine if a gene is sex-linked?
How would you determine if a gene is sex-linked?
Practice: Pedigree
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked: