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Practice: Pedigree

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Wize University Biology Textbook > Mendelian Genetics

Inheritance of X-Linked Traits

4 Activities

Wize University Biology Textbook > Mendelian Genetics

Inheritance of Autosomal Traits

3 Activities

Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:


More Inheritance of X-Linked Traits Questions:
Inheritance of traits practice problem 3
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
Dihybrid cross
Why are sex-linked diseases more likely to affect males?
Dihybrid cross
Why are sex-linked diseases more likely to affect males?
Inheritance of traits practice problem 3
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Pedigree practice problem 2
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Pedigree practice problem
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Inheritance of traits
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
How would you determine if a gene is sex-linked?
How would you determine if a gene is sex-linked?
A certain X-linked dominant disease in humans occurs when there are more than 30 repeats of a GAC trinucleotide in a particular gene. The unique sequence outside the repeat region is as follows:
5' CAGTATGCA------(GAC)n-------ATGCGTAAT 3'
3' GTCATACGT------(GAC)n-------TACGCATTA 5'
More Inheritance of Autosomal Traits Questions:
A young couple has undergone a successful in vitro fertilization procedure. The father has cystic fibrosis and the mother has a sister with cystic fibrosis. Both of these affected individuals have ~F508 mutations. Before making the decision to conceive, the couple underwent extensive genetic counseling regarding the potential risks of having a child with cystic fibrosis. However, the mother refused prenatal screening for CF as it would not affect the decision to raise their child. The family pedigree is diagrammed below with the unborn child
marked by the red arrow.
What is the chance that this child will have cystic fibrosis?
Inheritance of traits practice problem 3
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
Inheritance of traits practice problem 3
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Pedigree practice problem 2
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Pedigree practice problem
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked:
Inheritance of traits
In cats, big ears are dominant over short ears, and the gene is autosomal. Another gene controls eye colour, and is X-linked. "E" gives brown eyes, "e" gives blue eyes, and Ee gives green eyes.
Brown eyed male with the homozygous genotype for big ears is mated with a female with short ears and green eyes. What kittens could be produced?
Note: X-linked traits are on the X chromosome. Females have two X chromosomes while males have one X chromosome and one Y chromosome.
Why has human evolution not eradicated the sickle cell hemoglobin allele?
Individuals with Down’s syndrome have a trisomy of chromosome 21 that arose from a single error in meiosis. Imagine a child, Bella, who has parents with normal karyotypes. Only 1 of Bella’s chromosomes carries the same SNP as is found in her father. Which of the follow stages of meiosis could this error have occurred?
Meiosis I in the mother
Meiosis I in the father
A cystic-fibrosis mutation in a certain pedigree is due to a single nucleotide-pair (SNP) change. This change destroys an EcoRI restriction site normally found in this position.
a) How would you use this information in counseling members of this family about their likelihood of being carriers? State the precise experiments needed.
b) Assume that you find that a woman in this family is a carrier, and it transpires that she is married to an unrelated man who also is a heterozygote for cystic fibrosis, but, in his case, it is a different mutation in the same gene. How would you counsel this couple about the risks of a child’s having cystic fibrosis?
Based on the pedigree below, what type of trait is this?
You are examining a family in which both parents are known to be carriers for sickle cell anemia, which is a rare autosomal recessive disease with 2% of the population carrying the mutant allele. Their first child was born with the disease, and the parents have come to you to assess whether the new fetus is also diseased, is a carrier, or is homozygous normal. DNA samples from each family member and the fetus are tested by PCR and gel electrophoresis. The following results are obtained:
What is the probability that the child who will develop from this fetus will exhibit the disease?
When this child grows up and mates, what is the probability that any one of her children will be afflicted with the disease?
A young couple has undergone a successful in vitro fertilization procedure. The father has cystic fibrosis and the mother has a sister with cystic fibrosis. Both of these affected individuals have ~F508 mutations. Before making the decision to conceive, the couple underwent extensive genetic counseling regarding the potential risks of having a child with cystic fibrosis. However, the mother refused prenatal screening for CF as it would not affect the decision to raise their child. The family pedigree is diagrammed below with the unborn child
marked by the red arrow.
What is the chance that this child will have cystic fibrosis?
Practice: AD, AR or X?
Identify if pedigree is autosomal dominant, autosomal recessive, or X-linked: