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The Synapse

When the action potential reaches the end of an axon, how is this the information passed on to the next neuron (or to a muscle, or an organ, etc.)? The answer is: through a chemical synapse!
  • The action potential is an electrical signal that get transformed into a chemical signal at the synapse.
  • We call the neuron passing on the signal a pre-synaptic neuron; the neuron receiving the signal is a post-synaptic neuron.
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Synaptic Transmission

When the action potential reaches the axon terminal, synaptic vesicles full of neurotransmitters are released from the terminal into the synaptic cleft between the two cells.

The neurotransmitters bind to receptors on the post-synaptic cell. Receptors are lock and key - they specifically fit particular neurotransmitters

Neurotransmitters that don't bind to receptors can diffuse out, be broken down by enzymes or taken up again by the pre-synaptic neuron.
Photo by Young, KA., Wise, JA., DeSaix, P., Kruse, DH., Poe, B., Johnson, E., Johnson, JE., Korol, O., Betts, JG., & Womble, M. / CC BY


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The Action Potential

It is through the action potential that neurons pass information from one another. There are action potentials carrying the information from your eyes right now to your brain! There are several key things to know about the action potential:
  • Information travels only in one direction: from the axon hillock to the end of the axon of the neuron.
  • Neurons transmit information by a combination of chemical and electrical processes.
  • Electrical signal travels down the axon very fast.
  • Chemical signal is slower and travels only a short distance at the synapse.

Adapted from photo by OpenStax / CC BY

Wize Tip
Think of the electrical signal like sending a text message: it quickly arrives. The chemical signaling mediated by neurotransmitters is like sending a letter in the mail: it takes much longer to reach its recipient!


Practice: Neural Communication

When a neuron is at rest, its charge is _____________