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Prenatal Development


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Nervous System Development

Shortly after fertilization, the zygote develops the ectoderm, mesoderm, and endoderm.

Throughout development:
  1. Ectoderm develops into outer coverings of the body: skin, nails, cells of the nervous system and sense organs.
  2. Mesoderm develops into structures between the ectoderm and endoderm: bone, muscle, blood, etc.
  3. Endoderm develops into our inner lining (digestive tract), as well as liver, pancreas (also related to digestion).

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Neural Tube


At about 4-6 weeks after fertilization, the neural tube forms. The brain and spinal cord will develop out of this neural tube.

Photo by SUM1 / CC BY

If the neural tube fails to close properly, spina bifida and anencephaly can result.

Spina bifida results when the bottom part of the neural tube fails to close. Spina bifida can result in paralysis of the legs, lack of bowel and bladder control, and learning disabilities.

Anencephaly results when the top part of the neural tube fails to close. The brain either fails to develop or does not develop completely. Anencephaly is fatal.

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Prenatal Brain Development




Beginning at approximately 25 days, the brain begins to develop.

The prosencephalon becomes the forebrain.

The mesencephalon becomes the midbrain.

The rhombencephalon becomes the hindbrain.





Photo by TilmannR / Public Domain
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Prenatal Environment

Teratogen - an environmental agent (biological, chemical, or physical) that causes damage to the embryo or fetus during development.
  • Alcohol use can result in intellectual disability or Fetal Alcohol Spectrum Disorder
  • Smoking reduces oxygen in the developing fetus or embryo and can result in premature birth, low birth weight, stillbirth, and sudden infant death syndrome (SIDS)
  • Many drugs, including illegal drugs, prescription drugs, and over-the-counter drugs, can affect the developing fetus
  • Illnesses such as measles, HIV, herpes, and rubella can affect the developing fetus
  • Exposure to radiation can result in impaired growth, birth defects, abnormal brain function, and cancer later in life

Practice: Development of the Nervous System

The prosencephalon develops into the: