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Mutation

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Wize University Biology Textbook > DNA Replication & Repair

Types of DNA Mutations

8 Activities

You are studying the genetic codes of three phenotypically identical E. coli bacteria: HB99, HB100 and HB101. While studying their DNA sequences, you note that a point mutation has occurred in the same gene in each of the E. coli strains. The gene encodes for an enzyme required to methylate lysine 27 on Histone 3: H3K27.

HB99 sequence: ATGCGTCACGTCGA
HB100 sequence: ATGCGTTACGTCGA
HB101 sequence: ATGCGTGACGTCGA

You find that in HB99 and HB101, H3K27 appears to be methylated normally. Moreover, the methylating enzyme encoded by this gene appears in normal levels and appears to be correctly folded. Therefore, you conclude that a
mutation has arisen between these two strains.

However in HB100, the H3K27 is not methylated. Additionally, the methylating enzyme encoded by this gene exists in very low levels and the protein appears to be truncated. Therefore, you conclude that a
mutation has arisen in this strain.
More Types of DNA Mutations Questions:
The bong mutant of a yeast species Saccharomyces causes them to be restricted to generating ATP through glycolysis alone. Which of the follow statements could be a possible role of this mutation?
Practice: Protein Structure
A missense mutation arises in the amino acid sequence in which the residue R is substituted for A. Which of the following is most likely true?
Which of the following mutations would not affect translation?
Mutation
You are studying the genetic codes of three phenotypically identical E. coli bacteria: HB99, HB100 and HB101. While studying their DNA sequences, you note that a point mutation has in a the same gene in each of the E. coli strains. The gene encodes for an enzyme required to methylate lysine 27 on Histone 3: H3K27.
HB99 sequence: ATGCGTCACGTCGA
HB100 sequence: ATGCGTTACGTCGA
Which of the following mutations would not affect translation?
MCAT Practice Question
The bong mutant of a yeast species Saccharomyces causes them to be restricted to generating ATP through glycolysis alone. Which of the follow statements could be a possible role of this mutation?
A missense mutation arises in the amino acid sequence in which the residue R is substituted for A. Which of the following is most likely true?
Practice: Protein Structure
A missense mutation arises in the amino acid sequence in which the residue R is substituted for A. Which of the following is most likely true?
MCAT Practice Question
The bong mutant of a yeast species Saccharomyces causes them to be restricted to generating ATP through glycolysis alone. Which of the follow statements could be a possible role of this mutation?
A human cell has received a mutation and is unable to produce actin. What would be the result after mitosis?
A cell has a mutation that results in higher expression of the gene encoding p21. What would happen to the cell?
Retinoblastoma is a type of eye cancer caused by:
A. a mutation in the Rb transcriptional factor that its inhibited binding to DNA
B. a mutation in p53 that prevents it from recognition damaged DNA
Which of the following is most likely to occur due to a mutation in p21?
Mutation that leads to the substitution of one amino acid for another are called?
Which of the following is consistent with the observation that cancers have an important epigenetic component?
Some tumor supressor proteins are involved in DNA repair
Some carcinogens are not mutagens
A nonsense mutation in the drosophila bicoid gene would result in which of the following?
After two rounds of DNA replication an SNP has been introduced into a genes open reading frame but the protein product is the exact same as the gene product from the sequence without the SNP. What type of mutation is this?
If a single base pair was inserted into DNA coding for the second exon of a eukaryotic mRNA transcript with three exons and two introns, which of the following statements is most likely true about the resulting protein?
Imagine you are studying an E. coli gene that codes for a specific enzyme. You have isolated a mutant for this enzyme, where E. coli produces a shorter than normal form of the polypeptide, and thus the enzyme is not functional. What type of mutation most likely led to this mutant?
Which of the following are directly responsible for ensuring that cells do not replicate in the event of DNA damage?
Which of the following describes a nonsense mutation?
You discover through your genetic counsellor that you have an alteration in an mitochondrial transit sequence. Which of the following characteristics of your nuclear genome would have been altered?
The bong mutant of a yeast species Saccharomyces causes them to be restricted to generating ATP through glycolysis alone. Which of the follow statements could be a possible role of this mutation?
Which of the following could affect all of the primary, secondary, and tertiary structure
of a protein?
Practice: Protein Structure
A missense mutation arises in the amino acid sequence in which the residue R is substituted for A. Which of the following is most likely true?
Which of the following mutations would not affect translation?
Mutation
You are studying the genetic codes of three phenotypically identical E. coli bacteria: HB99, HB100 and HB101. While studying their DNA sequences, you note that a point mutation has in a the same gene in each of the E. coli strains. The gene encodes for an enzyme required to methylate lysine 27 on Histone 3: H3K27.
HB99 sequence: ATGCGTCACGTCGA
HB100 sequence: ATGCGTTACGTCGA
Which DNA mutation(s) involve changes to a single basepair?