Wize AP Biology Textbook > Cellular Respiration

The TCA [Citric Acid / Krebs] Cycle [short]

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The Citric Acid Cycle

Acetyl-CoA enters the citric acid cycle where it is oxidized to CO2. Remember that the Citric Acid cycle is a loop that requires entry of acetyl-CoA to keep going.
  • Oxaloacetate combines with acetyl to produce citrate, releasing CoA.
  • Each round of the citric acid cycle produces: 3 NADH, 1 FADH2, and 1 GTP.
  • All reactions are catalyzed in the mitochondrial matrix, each by a different enzyme.
  • The products of the cycle are high energy molecules that can now participate in the electron transport chain to produce lots of ATP.



Balance After Glycolysis + Pyruvate Processing + Citric Acid Cycle

  1. Glycolysis: 2 pyruvate, 2 ATP, 2 NADH
  2. Pyruvate processing: 2 acetyl-CoA, 2 NADH
  3. Citric acid cycle: 6 NADH, 2 FADH2, 2 GTP

NET REACTION: 4 ATP, 10 NADH, 2 FADH2
Where does the Krebs Cycle occur?

Practice: Products of TCA/Citric Acid/Krebs Cycle

What is generated through one turn of the citric acid cycle?

Practice: CO2 Released by Krebs Cycle

How many CO2CO_2 molecules are released per acetyl group that passes through the Krebs cycle?