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Glycolysis
- When phosphocreatine levels are low ATP must be produced
- GLUT4 transports glucose into the cytoplasm where glycolysis occurs
- Glucose is converted to 2 pyruvate molecules and there is a NET gain of two ATP and two NADH molecules
Reaction 1:
Reaction 2:
Reaction 3:
Reaction 4:
https://commons.wikimedia.org/wiki/File:F1,6BP-GADP,DHAP.PNG. akane700. Creative Commons Attribution-Share Alike 3.0 Unported license.
Reaction 5:
Reaction 6:
Reaction 7:
Reaction 8:
Reaction 9:
Reaction 10:
Glycolysis Overview
Wize Tip
Overview of Glycolysis
Step 1: 1 ATP consumed
Step 3: 1 ATP consumed
Step 6: 2 NADH produced
Step 7: 2 ATP produced
Step 10: 2 ATP Produced
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Regulating Glycolysis
- There are three steps that are regulated in glycolysis
- All have a large free energy change
- Also glucose availability
- Allosteric regulation: regulation through binging of an effector molecule to a site other than the active site
Step 1: Hexokinase
Inhibited by high product concentration
Step 3: PFK-1
Inhibited by large amount of ATP
Activated by large amounts of AMP and product
Step 10: Pyruvate kinase
Inhibited through phosphorylation
Inhibited by ATP, alanine, and acetyl-CoA
Activated by AMP and fructose-1,6-bisphosphate
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How many reactions in Glycolysis result in ATP production?
a. 4
b. 5
c. 2
d. 10
c. 2. ATP is produced in reaction 7 and reaction 10.
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Which step for glycolysis does triose phosphate isomerase perform?
a. Step 1: the conversion of glucose to G6P
b. Step 2: the conversion of G6P to F6P
c. Step 8: the conversion of 3-phosphoglycerate to 2-phosphoglycerate
d. Step 5: the conversion of dihydroxyacetone phosphate to glyceraldehyde 3-phosphate
d. dihydroxyacetone phosphate is a triose phosphate and it is rearranged (isomerase) to glyceraldyhyde 3-phaosphate
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Which three steps of glycolysis are regulated?
a. Step 1, Step 3, and Step 10
b. Step 4, Step 7, and Step 10
c. Step 1, Step 3, and Step 7
d. Step 3, Step 4, and Step 7
a. Step 1, Step 3, and Step 10
What is the overall yield of glycolysis and the key steps involved?
Glycolysis Overview
