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Wize University Biochemistry Textbook > Enzyme Catalysis

Enzyme Regulation

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Enzyme Regulation

1) Substrate Availability
  • Enzyme can only catalyze reaction if there is substrate present to act on

2) Covalent Modifications
  • Enzyme induced chemical changes to enzymes that can activate or de-activate enzymes

https://commons.wikimedia.org/wiki/File:Glcogen.glucose.pi.jpg. Clbt88. This work has been released into the public domain


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3) Allosteric Control
  • A regulatory molecule binds to a site on the enzyme, separate form the active site, and alters enzyme shape and function
  • Feedback inhibition
https://commons.wikimedia.org/wiki/File:Feedback_Inhibition.jpeg. Ayschan. This work has been released into the public domain


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4) Zymogens, Proenzymes
  • Inactive precursors of enzymes
  • Seen in digestive enzymes (activated when expelled from cell)
https://commons.wikimedia.org/wiki/File:Zymogen_activation.png. Joyjiang. This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported, 2.5 Generic, 2.0 Generic and 1.0 Generic license.