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Wize University Biology Textbook > The Plasma Membrane

Active Transport

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Active Transport

Also involves a carrier or transporter. There are two types: primary and secondary active transport.
  • Can transport solutes against its concentration gradient.
  • Therefore, requires the input of energy.
  • When there's no energy available, this cannot occur.

Primary Active Transport

  • ATP is used as the source of energy.
  • The transporter/carrier itself is an ATPase enzyme.
  • Carrier takes a phosphate from ATP, changing its conformation. Examples: Na+/K+ ATPase, Ca2+ ATPase, H+ ATPase, H+/K+ ATPase



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Secondary Active Transport

  • Also known as co-transport. Energy used is from the movement of one ion down its electrochemical gradient, while another ion moves up its gradient.
  • When both solutes move in the same direction, the carrier molecule is called a symporter (hitching a ride). Example: Na+/glucose cotransporter, Na+/amino acid cotransporter.
  • When solutes move in opposite directions, the carrier molecule used is called an antiporter (club is at capacity). Example: Na+/H+ exchanger, Cl-/HCO3-exchanger, Na+/Ca2+ exchanger.



Summary

  • Both require input of energy.
  • Both move solutes against their electrochemical gradients
  • Primary active transport uses ATPases.
  • Secondary active transport uses another molecule that moves down its gradient.
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Example: Build Your Own Transporter

Imagine you have to design a carrier to transport molecule X into a cell against its concentration gradient (it cannot cross the membrane through the phospholipid bilayer or a channel). The cellular environment in question has low ATP but abundant levels of Na+ ions in the extracellular space. How would you design this carrier to transport this molecule? What kind of transport would this be? Do you know any examples of this type of transport?

To design this carrier, several things should be considered:
1) The molecule to be transported will go against its concentration gradient: this will require active transport
2) The cell is low on ATP, but has lots of Na+: the sodium gradient can be used as the energy to transport the molecule
3) Since Na+ is abundant extracellularly, it will be going into the cell: the carrier should be a symporter

Therefore, designing a Na+/molecule X symporter would be a great solution to this problem. This carrier would be doing secondary active transport. Examples of this include the Na+/glucose or Na+/amino acid cotransporters.
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Mark Yourself Question
  1. Grab a piece of paper and try this problem yourself.
  2. When you're done, check the "I have answered this question" box below.
  3. View the solution and report whether you got it right or wrong.

Practice: Predict Entry Method

By what method would you predict that these molecules would enter the cell?

a) Oxygen:

b) Potassium:

c) Water:

d) Glucose:

Extra Practice
Active transport
Active transport requires which of the following
Which of the following graphs represents the transport of lactose by cells that use both facilitated diffusion and active transport for lactose? The inhibitor added is an ATP inhibitor.
Practice: Transport
How would each of the following molecules be transported into the cell? (aimple diffusion, facilitated diffusion, primary active transport, or secondary active transport).
1.
2.
Practice: ATP
What would happen to transport if cells could not produce ATP?
Practice: Membrane Transport 3
You are running an experiment in the lab to determine if your bacterial cells take up lactose using active transport, facilitated diffusion, or both. You add an ATP inhibitor to the culture and measure the ratio of lactose inside the cell vs. outside the cell over time. Based on the graph below, which type of transport is used by the cells?
Practice: Membrane Transport 1
By what method would you predict that these molecules would enter the cell?
a) Oxygen:
b) Potassium:
Which of the following is true regarding membrane transport?
Which of the following are accurate statements regarding membrane transport?
i. The entropy of the system decreases during active transport which is why it requires the use of ATP
ii. Passive diffusion functions because of an increase in entropy
Given the following graph, which best describes this type of transport?
Which of the following directly requires an input of energy?
Which of the following requires ATP?